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Quantity Strength Unit Price Price Cart
28 Tablets Premarin 0.625mg $1.46 $40.99
84 Tablets Premarin 0.625mg $1.39 $116.99



Premarin is most preferably used to cure the symptoms of menopause. The symptoms are hot flashes, and vaginal dryness, burning, and irritation. It has also gained its importance in the prevention of osteoporosis in postmenopausal women and maintains the decreasing level of estrogen in females. Premarin contains the active medicine called conjugated estrogen. Estrogen causes the growth and development of female sex organ and it also maintains the growth of secondary sexual characteristics of the female. It is also used in men and women to manage certain types of cancer.

Mechanism of action of Premarin:

Estrogen binds to nuclear receptors present in estrogen-responsive tissues. It increases the rate of production of DNA, RNA and some proteins. It reduces the secretion of hormones from the pituitary gland called as gonadotropins, luteinizing hormone, and follicle-stimulating hormone. Hence the elevated level of these hormones gets decreased in postmenopausal women and symptoms after menopause get reduced.

Under what conditions the use Premarin is contraindicated?

  • If a patient has known or suspected history of breast cancer or endometrial cancer.
  • Undiagnosed abnormal vaginal bleeding.
  • Liver dysfunction or disease.
  • Endometrial hyperplasia.
  • If women have hypertensive reaction with Premarin or its other ingredients.


 What are the drug interactions of Premarin?

Some drugs show interaction with Premarin such as Carbamazepine, Phenytoin, Phenobarbital, Warfarin, Heparin, Imipramine, Desipramine, Erythromycin, Rifampicin and some oral contraceptives.

How to store this medicine?

Store it carefully at room temperature, away from heat, sunlight and humidity. Keep it away children and pets.

What is the correct administration of Premarin?


The Premarin comes in tablet dosage form of different strengths are 0.3, 0.45, 0.9 and 1.25 mg.  It should be taken orally. The following dosage regimen according to diseased conditions:

  • For vaginal atrophy: Take 0.3 mg to 1.25 mg of Premarin per day continuously for 25 days and followed by 5 days off. The dose may be titrated on the basis of severity of disease.
  • Hypoestrogenism: Take 0.3 or 0.625 mg of Premarin daily.
  • Female Castration or Primary Ovarian Failure: Take 1.25 mg of Premarin daily.
  • For osteoporosis: Take 0.625 mg of Premarin daily.
  • For breast cancer: Take 10 mg of Premarin daily.   

What are the side effects of Premarin:

Premarin causes some unwanted effects on patient, who are getting treated with it: Headache, nausea, back pain, joint pain, vaginal bleeding, pain in abdomen, breast pain, excessively prolonged periods and breast enlargement.

What are the safety measures to follow while using this medicine?

    • Don't smoke or use tobacco while using this medicine because it may increase the risk of blood clot, stroke and heart attack in female above 35 years of age.
    • This medicine should not be used by pregnant ladies or breast feeding mothers.
    • If you have hypoparathyroidism, then use this medicine very carefully. Otherwise it may cause estrogen-induced hypocalcaemia.
    • Don't use  Premarin with medroxyprogesterone together because it may enhance the risk of breast cancer.
    • Premarin may increase the triglyceride level, so use it with caution if you already have high triglycerides or cholesterol problem.

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